Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases | Zendy

Qingfei Chu | Zendy; Xinyu Gu | Zendy; Qiuxian Zheng | Zendy; Jing Wang | Zendy; Haihong Zhu | Zendy

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Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases

Author(s) -

Qingfei Chu,

Xinyu Gu,

Qiuxian Zheng,

Jing Wang,

Haihong Zhu

Publication year - 2021

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2021/8900122

Subject(s) - necroptosis , programmed cell death , apoptosis , mitochondrion , microbiology and biotechnology , cirrhosis , liver cell , biology , cancer research , necrosis , cell , liver disease , medicine , biochemistry , genetics

In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases.

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