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Euryops arabicus  Steud ( E. arabicus ) belongs to the family Asteraceae. It has several uses in folk medicine in the Arabian Peninsula. The current study aimed at evaluating the wound healing properties of the  E. arabicus  extract in rats. Primarily,  E. arabicus  successfully accelerated cell migration  in vitro  and it also showed no signs of dermal toxicity. Topical application of  E. arabicus  extract (5% or 20%) expedited healing of excised skin in rats. Histological examinations indicated that  E. arabicus  shortened epithelization period, stimulated fibroblast activity, and increased collagen deposition in wound tissues. The plant extract exerted antioxidant activity as evidenced by inhibition of GSH depletion and MDA accumulation and enhanced mRNA expression of Sod1 in wound tissues collected at the end of the experiment. Further,  E. arabicus  inhibited the rise of TNF- α  and IL-1 β  in the skin wound region. The anti-inflammatory was confirmed by the observed down regulation of Ptgs2, Nos2, IL-6, and NF- κ B mRNA expression. In addition, the extract enhanced the expression of TGF- β 1 and HIF-1 α  in wounded skin tissues as indicated immunohistochemically. Conclusively,  E. arabicus  expedites excision wound healing in rats. Collagen-enhancing, anti-inflammatory, and antioxidant properties mediate the observed wound healing activity. These findings might contribute to our understanding of the ethnobotanical use of  E. arabicus  in wounds.

Euryops arabicus Promotes Healing of Excised Wounds in Rat Skin: Emphasis on Its Collagen-Enhancing, Antioxidant, and Anti-Inflammatory Activities