The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A | Zendy

Weiwei Sun | Zendy; Bin Zhang | Zendy; Qingli Bie | Zendy; Na Ma | Zendy; Na Liu | Zendy; Zewei Shao | Zendy

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The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A

Author(s) -

Weiwei Sun,

Bin Zhang,

Qingli Bie,

Na Ma,

Na Liu,

Zewei Shao

Publication year - 2021

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.1155/2021/8874360

Subject(s) - stem cell , embryonic stem cell , induced pluripotent stem cell , rna methylation , methylation , biology , rna , cancer stem cell , dna methylation , microbiology and biotechnology , epigenetics , cancer research , computational biology , genetics , methyltransferase , gene , gene expression

The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation modifications including N6-methyladenosine, 5-methylcytosine, and uridylation in embryonic stem cells, adult stem cells, induced pluripotent stem cells, and cancer stem cells, so as to provide new insights into the potential innovative treatments of cancer or other complex diseases.

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