Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer | Zendy

Jarupa Soongsathita | Zendy; Pranisa Jamjuntra | Zendy; Nuttavut Sumransub | Zendy; Supaporn Yangngam | Zendy; Marjorie De la Fuente | Zendy; Glauben Landskron | Zendy; Peti Thuwajit | Zendy; Marcela A. Hermoso | Zendy; Chanitra Thuwajit | Zendy

Open Access

Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer

Author(s) -

Jarupa Soongsathita,

Pranisa Jamjuntra,

Nuttavut Sumransub,

Supaporn Yangngam,

Marjorie De la Fuente,

Glauben Landskron,

Peti Thuwajit,

Marcela A. Hermoso,

Chanitra Thuwajit

Publication year - 2021

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.315

H-Index - 83

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/2021/8840066

Subject(s) - tumor microenvironment , immune system , cancer research , cancer associated fibroblasts , cytotoxic t cell , stromal cell , tumor progression , immunosuppression , immunology , biology , tumor infiltrating lymphocytes , myeloid derived suppressor cell , immunotherapy , cancer , medicine , suppressor , biochemistry , in vitro

Signals from the tumor microenvironment (TME) have a profound influence on the maintenance and progression of cancers. Chronic inflammation and the infiltration of immune cells in breast cancer (BC) have been strongly associated with early carcinogenic events and a switch to a more immunosuppressive response. Cancer-associated fibroblasts (CAFs) are the most abundant stromal component and can modulate tumor progression according to their secretomes. The immune cells including tumor-infiltrating lymphocytes (TILs) (cytotoxic T cells (CTLs), regulatory T cells (Tregs), and helper T cell (Th)), monocyte-infiltrating cells (MICs), myeloid-derived suppressor cells (MDSCs), mast cells (MCs), and natural killer cells (NKs) play an important part in the immunological balance, fluctuating TME between protumoral and antitumoral responses. In this review article, we have summarized the impact of these immunological players together with CAF secreted substances in driving BC progression. We explain the crosstalk of CAFs and tumor-infiltrating immune cells suppressing antitumor response in BC, proposing these cellular entities as predictive markers of poor prognosis. CAF-tumor-infiltrating immune cell interaction is suggested as an alternative therapeutic strategy to regulate the immunosuppressive microenvironment in BC.

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