Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage | Zendy

Zhenjia Yao | Zendy; Qinqin Bai | Zendy; Gaiqing Wang | Zendy

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Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

Author(s) -

Zhenjia Yao,

Qinqin Bai,

Gaiqing Wang

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/8815441

Subject(s) - oxidative stress , intracerebral hemorrhage , oxidative phosphorylation , pharmacology , chemistry , neuroscience , medicine , biology , biochemistry , subarachnoid hemorrhage

Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory response, apoptosis, autophagy, and blood-brain barrier (BBB) disruption. This review summarizes the current state of knowledge regarding the pathogenic mechanisms of brain injury after ICH, markers for detecting OS, and therapeutic strategies that target OS to mitigate brain injury.

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