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Objective. To investigate the quantity of CD4+T, CD4+T, CD8+T, and γδT cells in peripheral blood of HIV-infected/AIDS patients as well as to explore the possible role of CD4/CD8 ratio and γδT cells in the progression of HIV/AIDS, aimed at providing evidence for the diagnosis and treatment of AIDS. Methods. The quantity levels of CD3+T cells, CD4+T cells, CD8+T cells, and γδT cells in peripheral blood of 46 HIV-infected/AIDS patients and 30 healthy controls were detected by using flow cytometry. Results. The count of CD3+T, CD4+T, CD8+T, and γδT cells ( x ¯ ± s , A/μl) in the peripheral blood was  1183.64 ± 132.58 ,  278.39 ± 122.38 ,  863.13 ± 82.38 , and  22.53 ± 1.74 in the experimental group as well as  1456.46 ± 124.37 ,  788.74 ± 189.67 ,  569.61 ± 46.49 , and  10.96 ± 0.28 in the control group, respectively. The  p values of the two groups were &lt;0.005 after the  t -test, revealing a statistically significant difference. The proportion of CD3+T, CD4+T, CD8+T, and γδT cells in total lymphocytes in the two groups ( x ¯ ± s , %) was  71.83 ± 5.37 ,  13.39 ± 2.23 ,  62.93 ± 5.81 , and  3.67 ± 0.87 in the experimental group, respectively. In the control group, the values were expressed as  66.72 ± 5.48 ,  42.77 ± 3.38 ,  31.41 ± 3.62 , and  1.73 ± 0.36 , respectively. After performing the  t -test,  p values in the two groups were &lt;0.005 except CD3+T, with statistically significant differences. Besides, CD4/CD8 was  0.33 ± 0.11 in the experimental group and  1.48 ± 0.29 in the control group,  t = 26.528 , p &lt; 0.001 , exhibiting a significant statistical difference. Conclusion. HIV infection induces the activation and proliferation of CD8+T and γδT cells, contributing to the decrease of CD4+T cells, while CD8+T and γδT cells are involved in the immune response and tissue damage after HIV infection.

CD3+T, CD4+T, CD8+T, and CD4+T/CD8+T Ratio and Quantity of γδT Cells in Peripheral Blood of HIV-Infected/AIDS Patients and Its Clinical Significance