Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer | Zendy

Tongwu Bie | Zendy; Xuewen Zhang | Zendy

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Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer

Author(s) -

Tongwu Bie,

Xuewen Zhang

Publication year - 2021

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/2021/8569575

Subject(s) - head and neck squamous cell carcinoma , head and neck cancer , biomarker , cancer research , oncology , western blot , medicine , cancer , biology , gene , genetics

Secreted phosphoprotein 1 (SPP1) participated in various biological processes in many cancers, including immune response, tumor progression, and prognosis. However, SPP1 in head and neck squamous cell carcinoma (HNSCC) remains unknown. Clinical-genetic data of HNSCC were obtained from The Cancer Genome Atlas (TCGA) database. The differential expression of SPP1 in HNSCC tissues and adjacent normal tissues was quantified by bioinformatics methods and verified by western blot and other differential biological methods. We concluded that SPP1 is significantly upregulated in tumor tissues and can become a prognostic biomarker for HNSCC.

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