Immune Thrombocytopenia Associated with Hepatitis B Virus and Autoimmune Hepatitis and Recovery of Platelet Count following Liver Transplantation | Zendy

Chloe K. Nobuhara | Zendy; Diana M. Cardona | Zendy; Murat O. Arcasoy | Zendy; Carl L. Berg | Zendy; Andrew S. Barbas | Zendy

Open Access

Immune Thrombocytopenia Associated with Hepatitis B Virus and Autoimmune Hepatitis and Recovery of Platelet Count following Liver Transplantation

Author(s) -

Chloe K. Nobuhara,

Diana M. Cardona,

Murat O. Arcasoy,

Carl L. Berg,

Andrew S. Barbas

Publication year - 2021

Publication title -

case reports in transplantation

Language(s) - English

Resource type - Journals

eISSN - 2090-6943

pISSN - 2090-6951

DOI - 10.1155/2021/8484106

Subject(s) - medicine , thrombopoietin receptor , autoimmune hepatitis , autoimmune thrombocytopenia , liver transplantation , immunology , hepatitis b virus , thrombopoietin , hepatitis , hepatitis b , romiplostim , coagulopathy , virus , transplantation , virology , platelet , biology , stem cell , haematopoiesis , genetics

Immune thrombocytopenia is a consumptive coagulopathy that can be either idiopathic or associated with infectious or autoimmune etiologies. Here, we present a case of immune thrombocytopenia in the setting of acute liver failure due to coexisting diagnoses of hepatitis B virus and autoimmune hepatitis. Our patient underwent orthotopic liver transplantation and recovered hemostatic platelet counts after treatment with romiplostim, a thrombopoietin receptor agonist, 51 days after transplantation. To our knowledge, this is the first case report of immune thrombocytopenia secondary to both hepatitis B virus and autoimmune hepatitis in a patient with acute liver failure.

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