Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma | Zendy

Kaushik Mandal | Zendy; Damilola Ashorobi | Zendy; Alice Lee | Zendy; Huijuan Liao | Zendy; Salini Chellappan Kumar | Zendy; David S. H. Rosenthal | Zendy

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Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma

Author(s) -

Kaushik Mandal,

Damilola Ashorobi,

Alice Lee,

Huijuan Liao,

Salini Chellappan Kumar,

David S. H. Rosenthal

Publication year - 2021

Publication title -

case reports in endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.26

H-Index - 6

eISSN - 2090-6501

pISSN - 2090-651X

DOI - 10.1155/2021/8479193

Subject(s) - medicine , paraproteins , paraproteinemia , multiple myeloma , levothyroxine , euthyroid , medical diagnosis , triiodothyronine , thyroid , monoclonal , pathology , immunology , antibody , monoclonal antibody

Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report an additional case of a patient with multiple myeloma and an IgG paraproteinemia who had such a spurious elevation of total T3 complicating her levothyroxine management of hypothyroidism. In addition, we alert clinicians that differences in performance characteristics between various manufacturers' test platforms may also cause spurious reports.

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