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Materials and Methods   Clinical strains of  Aggregatibacter actinomycetemcomitans  and  Eikenella corrodens  and two reference strains of  A. actinomycetemcomitans  were tested. The antibacterial activity of each studied plant extract was evaluated using agar diffusion and broth microdilution assays.Results   Both aqueous and methanolic extracts of  M. communis  exhibited high antibacterial activity against periodontal pathogens as compared to  M. vulgare  extracts. At concentrations of 2.5-0.32 mg/disc, inhibition zones of the methanolic extract of  M. communis  ranged from 19.66 ± 0.57 to 12.33 ± 0.57 mm. The methanolic extract of  M. vulgare  showed at concentrations of 5-0.63 mg/disc inhibition zones ranging from 15.66 ± 0.57 to 12 ± 0.00 mm. Its aqueous extract at concentration of 0.63 mg/disc showed no antimicrobial activity against the clinical and reference strain of  A. actinomycetemcomitans. Conclusion . This study showed that methanolic and aqueous extracts of  M. communis  and  M. vulgare  have in vitro an antibacterial activity against periodontal pathogens. They could be use as ingredients of an oral antimicrobial agent for prevention or treatment of periodontal diseases. Further research on isolating the compounds from these plant extracts and their toxicity effect could be conducted.

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In Vitro Antibacterial Activity of Myrtus communis L. and Marrubium vulgare L. Leaves against Aggregatibacter actinomycetemcomitans and Eikenella corrodens