The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review | Zendy

Fang Liu | Zendy; Jiawei Xu | Zendy; Linliang Wu | Zendy; Tiantian Zheng | Zendy; Qi Han | Zendy; Yunyun Liang | Zendy; Liling Zhang | Zendy; Guicai Li | Zendy; Yumin Yang | Zendy

Open Access

The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

Author(s) -

Fang Liu,

Jiawei Xu,

Linliang Wu,

Tiantian Zheng,

Qi Han,

Yunyun Liang,

Liling Zhang,

Guicai Li,

Yumin Yang

Publication year - 2021

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.1155/2021/8124444

Subject(s) - regeneration (biology) , materials science , peripheral nerve , tissue engineering , adhesion , extracellular matrix , groove (engineering) , biomedical engineering , nanotechnology , anatomy , medicine , microbiology and biotechnology , biology , composite material , metallurgy

The surface topographies of artificial implants including surface roughness, surface groove size and orientation, and surface pore size and distribution have a great influence on the adhesion, migration, proliferation, and differentiation of nerve cells in the nerve regeneration process. Optimizing the surface topographies of biomaterials can be a key strategy for achieving excellent cell performance in various applications such as nerve tissue engineering. In this review, we offer a comprehensive summary of the surface topographies of nerve implants and their effects on nerve cell behavior. This review also emphasizes the latest work progress of the layered structure of the natural extracellular matrix that can be imitated by the material surface topology. Finally, the future development of surface topographies on nerve regeneration was prospectively remarked.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research