Protective Effect and Mechanism of Bone Morphogenetic Protein-4 on Apoptosis of Human Lens Epithelium Cells under Oxidative Stress | Zendy

Bei Du | Zendy; Jialin Zheng | Zendy; Liangyu Huang | Zendy; Hong Zhang | Zendy; Qiong Wang | Zendy; Yaru Hong | Zendy; Xiaomin Zhang | Zendy; Xiaorong Li | Zendy; Lijie Dong | Zendy

Open Access

Protective Effect and Mechanism of Bone Morphogenetic Protein-4 on Apoptosis of Human Lens Epithelium Cells under Oxidative Stress

Author(s) -

Bei Du,

Jialin Zheng,

Liangyu Huang,

Hong Zhang,

Qiong Wang,

Yaru Hong,

Xiaomin Zhang,

Xiaorong Li,

Lijie Dong

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/8109134

Subject(s) - oxidative stress , microbiology and biotechnology , bone morphogenetic protein , reactive oxygen species , apoptosis , lens (geology) , transcription factor , inflammation , cataracts , transforming growth factor , biology , chemistry , endocrinology , immunology , biochemistry , genetics , gene , paleontology

Bone morphogenetic proteins (BMPs), a member of the transforming growth factor β (TGF- β ) superfamily, are abundant in human ocular tissues and play an important role in lens development. Targeted deletion of BMP-4 in mice results in failure of lens placode formation. Following lens maturation, the formation of senile cataracts is demonstrably associated with free radical-related oxidative stress. Previous studies reported that BMPs play an antiapoptotic role in cells under oxidative stress, and the BMP-4 signal is important in inflammation regulation and homeostasis. BMP-4 evidently suppressed the apoptosis of human lens epithelial cells (HLECS) under oxidative stress induced by H 2 O 2 . This protective antiapoptotic effect is partly due to a decrease in caspase-3 activity and reactive oxygen species (ROS) level. Furthermore, the expression of activating transcription factor- (ATF-) 6 and Krüppel-like factor- (KLF-) 6 increased under oxidative stress and decreased after BMP-4 treatment.

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