Open AccessSchisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma
Author(s) -
Yaqin Chen,
Yu Kong,
Qili Wang,
Jian Chen,
Hua Chen,
Huihui Xie,
Lan Li
Publication year - 2021
Publication title -
journal of immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 83
eISSN - 2314-8861
pISSN - 2314-7156
DOI - 10.1155/2021/8029963
Subject(s) - ovalbumin , schisandra chinensis , pharmacology , nf κb , medicine , asthma , antioxidant , inflammation , immunology , immunoglobulin e , chemistry , immune system , traditional chinese medicine , antibody , biochemistry , alternative medicine , pathology
Background Asthma is a complex inflammatory disorder that plagues a large number of people. Schisandrin B is an active ingredient of the traditional Chinese herbal medicine Schisandra with various proven physiological activities such as anti-inflammatory and antioxidant activities. In this study, we explored the anti-inflammatory and antioxidant effects and provided the mechanistic insights into the activity of schisandrin B in a mouse model of ovalbumin- (OVA-) induced allergic asthma.Methods Male BALB/c mice were sensitized and challenged with OVA to induce asthma and treated with various doses (15 mg/kg, 30 mg/kg, and 60 mg/kg) of SCH to alleviate the features of allergic asthma, airway hyperresponsiveness, inflammatory response, OVA-specific immunoglobulin (Ig)E level, and pathological injury.Results Schisandrin B significantly attenuated the airway hyperresponsiveness induced by OVA. Moreover, schisandrin B administration suppressed inflammatory responses, reduced the level of IgE, and attenuated pathological injury. Mechanistically, schisandrin B treatment promoted the activation of nuclear erythroid 2-related factor 2 (Nrf2), but suppressed the stimulation of the NF- κ B pathway caused by OVA.Conclusion Taken together, our study suggests that schisandrin B attenuates the features of asthmatic lungs by inhibiting the NF- κ B pathway and activating the Nrf2 signaling pathway.