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Objectives   The aim of this study was to evaluate the shear bond strength and the nanoleakage expression of CLEARFIL Universal Bond Quick and Tetric N-Bond adhesive systems bonded to dentin.Materials and Methods   100 freshly extracted human premolar teeth were utilized. The teeth were sectioned to expose dentin. All dentin specimens were assigned into 4 experimental groups; 2 groups had Universal Bond Quick (Universal self  group) and Tetric N-Bond (Tetric self  group) applied in the self-etch mode, while 2 groups had Universal Bond Quick (Universal total  group) and Tetric N-Bond (Tetric total  group) applied in the total-etch mode.  n  = 15 for shear bond strength and  n  = 10 for nanoleakage experiment. One-way ANOVA and Kruskal-Wallis test were utilized to analyze the shear bond strength test and the nanoleakage expression, respectively.Results   The highest significant bond strength value was recorded by the Tetric self  specimens ( p  < 0.05) when compared to the remaining three groups. There were no statistically significant differences between the shear bond strength values recorded in the Tetric total , Universal self , and Universal total  groups ( p  < 0.05). Both bonding systems applied in the self-etch mode (Universal self , Tetric self ) had no silver nitrate deposits in the hybrid layer and the hybrid layer-adhesive interface ( p  < 0.001); however, both bonding systems applied in the total-etch mode (Universal total , Tetric total ) had silver nitrate deposits in the hybrid layer, the hybrid layer-adhesive interface, and the bonding layer ( p  < 0.001).Conclusion   Applying the Universal Bond Quick and Tetric N-Bond in the self-etch mode exhibited better results in terms of nanoleakage expression. Universal Bond Quick showed the stability of the shear bond strength to dentin when applied using the total-etch or self-etch modes. Tetric N-Bond showed significant deterioration in bond strength when applied in the total-etch mode and exhibited the highest bond strength when applied in the self-etch mode.

Application Modes Affect Two Universal Adhesive Systems’ Nanoleakage Expression and Shear Bond Strength