Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential | Zendy

Lihua Ni | Zendy; Yuan Cheng | Zendy; Xiaoyan Wu | Zendy

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Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential

Author(s) -

Lihua Ni,

Yuan Cheng,

Xiaoyan Wu

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/7277966

Subject(s) - endoplasmic reticulum , unfolded protein response , diabetic nephropathy , medicine , pathogenesis , apoptosis , pathological , nephrology , pharmacology , endocrinology , bioinformatics , kidney , cancer research , microbiology and biotechnology , biology , biochemistry

Recent progress has been made in understanding the roles and mechanisms of endoplasmic reticulum (ER) stress in the development and pathogenesis of diabetic nephropathy (DN). Hyperglycemia induces ER stress and apoptosis in renal cells. The induction of ER stress can be cytoprotective or cytotoxic. Experimental treatment of animals with ER stress inhibitors alleviated renal damage. Considering these findings, the normalization of ER stress by pharmacological agents is a promising approach to prevent or arrest DN progression. The current article reviews the mechanisms, roles, and therapeutic aspects of these findings.

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