Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier | Zendy

Shanshan Chen | Zendy; Ruonan He | Zendy; Beihui He | Zendy; Li Xu | Zendy; Shuo Zhang | Zendy

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Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier

Author(s) -

Shanshan Chen,

Ruonan He,

Beihui He,

Li Xu,

Shuo Zhang

Publication year - 2021

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.315

H-Index - 83

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/2021/7183136

Subject(s) - immune system , microvesicles , biology , exosome , intestinal mucosa , microrna , microbiology and biotechnology , immunology , immunity , acquired immune system , cell , ccl18 , medicine , gene , genetics

The intestinal mucosal immune barrier protects the host from the invasion of foreign pathogenic microorganisms. Immune cells and cytokines in the intestinal mucosa maintain local and systemic homeostasis by participating in natural and adaptive immunity. Deficiency of the intestinal mucosal immune barrier is associated with a variety of intestinal illnesses. Exosomes are phospholipid bilayer nanovesicles that allow cell-cell communication by secreting physiologically active substances including proteins, lipids, transcription factors, mRNAs, micro-RNAs (miRNAs), and long noncoding RNAs (lncRNAs). Exosomal lncRNAs are involved in immune cell differentiation and the modulation of the immune response. This review briefly introduces the potential role of exosomal lncRNAs in the intestinal mucosal immune barrier and discusses their relevance to intestinal illnesses.

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