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The identification of biomarkers plays an important role in the diagnosis and prognosis of cancers. In this study, we explored the diagnostic and prognostic value of the  FLAD1  expression across pan-cancer analysis from online databases (Oncomine, cBioPortal, Breast Cancer Gene-Expression Miner, UALCAN, GEO, BCIP, TNMplot, ENCORI, Kaplan-Meier Plotter, and LinkedOmics). We found that  FLAD1  was overexpressed in a number of different kinds of cancers, especially in breast cancer, and higher  FLAD1  expression level was associated with the HER+, p53 mutant, node-involved, NPI stage 3, basal-like, and triple-negative groups compared with the other subgroups of breast cancer. The  FLAD1  expression levels were higher in patients that were 21–40 years old than those in patients of other ages and were higher in the African-American group than in the Caucasian group. We also analyzed the  FLAD1- related microRNAs and their prognostic values in breast cancer. This study highlights the significance of  FLAD1  in cancers and provides evidence for its potential as a biomarker for the diagnosis and prognosis of cancers.

Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis