Microcomputed Tomography and Histological Study of Bone Regeneration Using Tooth Biomaterial with BMP-2 in Rabbit Calvarial Defects | Zendy

Puneet Wadhwa | Zendy; Jeong Hun Lee | Zendy; Bing Zhao | Zendy; HongXin Cai | Zendy; Jae-Suk Rim | Zendy; Hyon-Seok Jang | Zendy; EuiSeok Lee | Zendy

Open Access

Microcomputed Tomography and Histological Study of Bone Regeneration Using Tooth Biomaterial with BMP-2 in Rabbit Calvarial Defects

Author(s) -

Puneet Wadhwa,

Jeong Hun Lee,

Bing Zhao,

HongXin Cai,

Jae-Suk Rim,

Hyon-Seok Jang,

EuiSeok Lee

Publication year - 2021

Publication title -

scanning

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.359

H-Index - 47

eISSN - 1932-8745

pISSN - 0161-0457

DOI - 10.1155/2021/6690221

Subject(s) - calvaria , biomaterial , endochondral ossification , intramembranous ossification , bone morphogenetic protein 2 , dentistry , regeneration (biology) , biomedical engineering , bone formation , bone morphogenetic protein , chemistry , materials science , anatomy , medicine , microbiology and biotechnology , cartilage , biology , in vitro , biochemistry , gene

Our study was aimed to analyze the osteoinductive effect of powdered and block type autogenous bone graft along with bone morphogenetic protein (BMP-2) as compared to synthetic bone graft. Three circular bicortical defects were made in the calvaria of each rabbit and randomly divided into three groups as follows: powdered tooth biomaterial+BMP-2, block tooth biomaterial+BMP-2, and control group: synthetic bone+BMP-2. The samples taken from these defects after 4 and 8 weeks were analyzed histologically along with micro CT analysis. In our study, both powered and block type tooth autogenous bone graft successfully stimulated mesenchymal cells leading to endochondral ossification and bone regeneration. We observed that the powered bone graft material which is acid insoluble especially is preferable as a carrier for BMP-2.

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