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The breast cancer microscopy images acquire information about the patient’s ailment, and the automated mitotic cell detection outcomes have generally been utilized to ease the massive amount of pathologist’s work and help the pathologists make clinical decisions quickly. Several previous methods were introduced to solve automated mitotic cell count problems. However, they failed to differentiate between mitotic and nonmitotic cells and come up with an imbalance problem, which affects the performance. This paper proposes a Representation Differential Learning Method (RDLM) for mitosis detection through deep learning to detect the accurate mitotic cell area on pathological images. Our proposed method has been divided into two parts: Global bank Feature Pyramid Network (GLB-FPN) and focal loss (FL). The GLB feature fusion method with FPN essentially makes the encoder-decoder pay attention, to further extract the region of interest (ROIs) for mitotic cells. On this basis, we extend the GLB-FPN with a focal loss to mitigate the data imbalance problem during the training stage. Extensive experiments have shown that RDLM significantly outperforms on visualization view and achieves the best performance in quantitative matrices than other proposed approaches on the MITOS-ATYPIA-14 contest dataset. Our framework reaches a 0.692 F1-score. Additionally, RDLM achieves 5% improvements than GLB with FPN in F1-score on the mitosis detection task.

Representation of Differential Learning Method for Mitosis Detection