The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches | Zendy

Xin Xing | Zendy; Yongrui Bai | Zendy; Jian Song | Zendy

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The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches

Author(s) -

Xin Xing,

Yongrui Bai,

Jian Song

Publication year - 2021

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.315

H-Index - 83

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/2021/6687474

Subject(s) - tumor microenvironment , chemotaxis , stromal cell , mesenchymal stem cell , cancer research , tumor cells , metastasis , immunotherapy , biology , cancer , microbiology and biotechnology , immunology , immune system , receptor , genetics , biochemistry

The recruitment of neutrophil to the primary cancer has been shown to be steered by neoplastic cells or tumor-educated mesenchymal stromal cells and has a prometastatic effect. However, the neutrophil chemotaxis and their interaction with tumor cells in the distal metastasized tissues remain elusive. In this review, we discussed emerging research on the interaction between neutrophil recruitment and tumor metastasis, which is essential for studying tumor cell invasion and related immunotherapy.

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