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During X chromosome inactivation, many chromatin changes occur on the future inactive X chromosome, including acquisition of a variety of repressive covalent histone modifications, heterochromatin protein associations, and DNA methylation of promoters. Here, we summarize  trans -acting factors and  cis  elements that have been shown to be involved in the human inactive X chromosome organization and compaction.

trans-Acting Factors and cis Elements Involved in the Human Inactive X Chromosome Organization and Compaction