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Background   The effects of dose reduction in lung nodule detection need better understanding.Purpose   To compare the detection rate of simulated lung nodules in a chest phantom using different computed tomography protocols, low dose (LD), ultralow dose (ULD), and conventional (CCT), and to quantify their respective amount of radiation.Materials and Methods   A chest phantom containing 93 simulated lung nodules was scanned using five different protocols: ULD (80 kVp/30 mA), LD A (120 kVp/20 mA), LD B (100 kVp/30 mA), LD C (120 kVp/30 mA), and CCT (120 kVp/automatic mA). Four chest radiologists analyzed a selected image from each protocol and registered in diagrams the nodules they detected. Kruskal–Wallis and McNemar's tests were performed to determine the difference in nodule detection. Equivalent doses were estimated by placing thermoluminescent dosimeters on the surface and inside the phantom.Results   There was no significant difference in lung nodules' detection when comparing ULD and LD protocols ( p =0.208 to  p =1.000), but there was a significant difference when comparing each one of those against CCT ( p  < 0.001). The detection rate of nodules with CT attenuation values lower than −600 HU was also different when comparing all protocols against CCT ( p  < 0.001 to  p =0.007). There was at least moderate agreement between observers in all protocols ( κ -value >0.41). Equivalent dose values ranged from 0.5 to 9 mSv.Conclusion   There is no significant difference in simulated lung nodules' detection when comparing ULD and LD protocols, but both differ from CCT, especially when considering lower-attenuating nodules.

Dosimetry and Comparison between Different CT Protocols (Low Dose, Ultralow Dose, and Conventional CT) for Lung Nodules’ Detection in a Phantom