Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research | Zendy

Yu Zhou | Zendy; Sujie Ke | Zendy; Kejun Wu | Zendy; Jingze Huang | Zendy; Xuelin Gao | Zendy; Beibei Li | Zendy; Xiaoying Lin | Zendy; Xiaohong Liu | Zendy; Xiaoying Liu | Zendy; Li Ma | Zendy; Linxi Wang | Zendy; Wu Li | Zendy; Lijuan Wu | Zendy; Chengwen Xie | Zendy; Junjun Xu | Zendy; Yanping Wang | Zendy; Libin Liu | Zendy

Open Access

Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research

Author(s) -

Yu Zhou,

Sujie Ke,

Kejun Wu,

Jingze Huang,

Xuelin Gao,

Beibei Li,

Xiaoying Lin,

Xiaohong Liu,

Xiaoying Liu,

Li Ma,

Linxi Wang,

Wu Li,

Lijuan Wu,

Chengwen Xie,

Junjun Xu,

Yanping Wang,

Libin Liu

Publication year - 2021

Publication title -

international journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.875

H-Index - 60

eISSN - 1687-8345

pISSN - 1687-8337

DOI - 10.1155/2021/6663553

Subject(s) - medicine , subclinical infection , cross sectional study , obesity , correlation , thyroid , endocrinology , homeostasis , physiology , pathology , geometry , mathematics

Objective It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population.Methods Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 193 subjects with SCH (90 males and 103 females) without a history of treatment of thyroid disease, such as surgery, radiation, and thyroid hormone or antithyroid medication, were included in the present study. Indices of obesity, including body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR) were measured.Results Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel's thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all p < 0.05). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all p < 0.05).Conclusions These results suggest that low levels of thyroid homeostasis indexes may be associated with overall obesity in SCH, rather than central adiposity.

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