Enhancing the Therapeutic Potential of Mesenchymal Stem Cells with Light‐Emitting Diode: Implications and Molecular Mechanisms | Zendy

Bárbara Sampaio Dias Martins Mansano | Zendy; Vitor Pocani da Rocha | Zendy; Ednei Luíz Antonio | Zendy; Daniele Fernanda Peron | Zendy; Rafael do Nascimento de Lima | Zendy; Paulo José Ferreira Tucci | Zendy; Andrey Jorge Serra | Zendy

Open Access

Enhancing the Therapeutic Potential of Mesenchymal Stem Cells with Light‐Emitting Diode: Implications and Molecular Mechanisms

Author(s) -

Bárbara Sampaio Dias Martins Mansano,

Vitor Pocani da Rocha,

Ednei Luíz Antonio,

Daniele Fernanda Peron,

Rafael do Nascimento de Lima,

Paulo José Ferreira Tucci,

Andrey Jorge Serra

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/6663539

Subject(s) - mesenchymal stem cell , stem cell , kinase , microbiology and biotechnology , protein kinase a , medicine , cancer research , chemistry , bioinformatics , biology

This study evaluated the effects of light-emitting diode (LED) on mesenchymal stem cells (MSCs). An electronic search was conducted in PubMed/MEDLINE, Scopus, and Web of Science database for articles published from 1980 to February 2020. Ten articles met the search criteria and were included in this review. The risk of bias was evaluated to report quality, safety, and environmental standards. MSCs were derived from adipose tissue, bone marrow, dental pulp, gingiva, and umbilical cord. Protocols for cellular irradiation used red and blue light spectrum with variations of the parameters. The LED has been shown to induce greater cellular viability, proliferation, differentiation, and secretion of growth factors. The set of information available leads to proposing a complex signaling cascade for the action of photobiomodulation, including angiogenic factors, singlet oxygen, mitogen-activated protein kinase/extracellular signal-regulated protein kinase, Janus kinase/signal transducer, and reactive oxygen species. In conclusion, although our results suggest that LED can boost MSCs, a nonuniformity in the experimental protocol, bias, and the limited number of studies reduces the power of systematic review. Further research is essential to find the optimal LED irradiation parameters to boost MSCs function and evaluate its impact in the clinical setting.

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