Transformation of Two Cases of Lung Adenocarcinoma into Pulmonary Sarcomatoid Carcinoma following Treatment | Zendy

Zhenyu Yang | Zendy; Yinfang Shen | Zendy; Junhong Jiang | Zendy; Ziyi Liu | Zendy; Chuanyong Mu | Zendy

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Transformation of Two Cases of Lung Adenocarcinoma into Pulmonary Sarcomatoid Carcinoma following Treatment

Author(s) -

Zhenyu Yang,

Yinfang Shen,

Junhong Jiang,

Ziyi Liu,

Chuanyong Mu

Publication year - 2021

Publication title -

canadian respiratory journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.675

H-Index - 53

eISSN - 1916-7245

pISSN - 1198-2241

DOI - 10.1155/2021/6661772

Subject(s) - medicine , adenocarcinoma , sarcomatoid carcinoma , lung cancer , lung , immunohistochemistry , basal cell , pathology , transformation (genetics) , carcinoma , malignant transformation , oncology , cancer , gene , biology , biochemistry

Accumulating evidence shows that histologic transformation is involved in the drug resistance of lung cancer. Moreover, it is common for lung adenocarcinoma to transform into small-cell lung cancer or squamous cell carcinoma; however, clinical cases with sarcomatoid transformation have been rarely reported. Thus, both the diagnosis and treatment of lung adenocarcinoma with sarcomatoid transformation remain difficult. Here, we discuss two patients with lung adenocarcinoma with sarcomatoid transformation—analyzing the diagnosis, clinical features, immunohistochemical characteristics, therapy, and prognosis—with the hope that this report will be used as a reference for future treatment of these patients.

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