Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases | Zendy

Lingfei Li | Zendy; Zhumei Ni | Zendy; Xiaoli Si | Zendy; Lin Jiang | Zendy; Hongfei Sang | Zendy; Wenqing Xia | Zendy; Zhenzhen Chen | Zendy; Jinyu Huang | Zendy; Jingfen Jin | Zendy; Anwen Shao | Zendy; Congguo Yin | Zendy

Open Access

Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases

Author(s) -

Lingfei Li,

Zhumei Ni,

Xiaoli Si,

Lin Jiang,

Hongfei Sang,

Wenqing Xia,

Zhenzhen Chen,

Jinyu Huang,

Jingfen Jin,

Anwen Shao,

Congguo Yin

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/6659908

Subject(s) - oxidative stress , biology , biogenesis , neuroscience , circular rna , regulation of gene expression , nervous system , bioinformatics , gene , computational biology , microrna , microbiology and biotechnology , genetics , biochemistry

Circular RNAs (circRNAs) are novel noncoding RNAs that play regulatory roles in gene expression. Dysregulation of circRNAs is associated with the development and progression of several diseases, such as diabetes mellitus, nervous system diseases, cardiovascular diseases, and cancer. CircRNAs functionally participate in cell physiological activities through various molecular mechanisms. However, these molecular mechanisms are unclear. Oxidative stress is an essential factor in the pathogenesis of various diseases, including neurological diseases. Emerging roles of circRNAs have been identified in different systems in response to oxidative stress. In this review, we summarize the current understanding of circRNA biogenesis, properties, expression profiles, and the clues indicating the regulatory roles of circRNAs through oxidative stress in various systems, especially the nervous system.

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