Open AccessA New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems
Author(s) -
Thuc Dinh Ngoc,
Vu Thi Ha,
Luong Ngo Xuan,
Huan Trinh Thi,
Hương Nguyễn Thị,
Mai Nguyen Thi Ngoc,
Tran Huu Giap,
Oanh Vu Thi Kim,
Thanh Nguyen Le
Publication year - 2021
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.436
H-Index - 50
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2021/6659106
Subject(s) - chemistry , scopoletin , antimicrobial , cytotoxicity , alkaloid , vanillin , friedelin , stereochemistry , phytochemical , ferulic acid , chelerythrine , organic chemistry , biochemistry , in vitro , protein kinase c , medicine , alternative medicine , triterpenoid , pathology , enzyme
Phytochemical study of Rourea oligophlebia stems led to the isolation of a new 2-pyrrolidone alkaloid (R,S)-N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1), together with 14 known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15). Several isolated compounds were evaluated for cytotoxicity and antimicrobial activity. Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 8–10 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively.
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