Discovery of a Novel Long Noncoding RNA Lx8-SINE B2 as a Marker of Pluripotency | Zendy

Fuquan Chen | Zendy; Miao Zhang | Zendy; Xiao Feng | Zendy; Xiaomin Li | Zendy; Haotian Sun | Zendy; Xinyi Lu | Zendy

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Discovery of a Novel Long Noncoding RNA Lx8-SINE B2 as a Marker of Pluripotency

Author(s) -

Fuquan Chen,

Miao Zhang,

Xiao Feng,

Xiaomin Li,

Haotian Sun,

Xinyi Lu

Publication year - 2021

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.1155/2021/6657597

Subject(s) - sox2 , homeobox protein nanog , biology , sine , transcription (linguistics) , long non coding rna , rna , embryonic stem cell , computational biology , genetics , microbiology and biotechnology , induced pluripotent stem cell , gene , mathematics , linguistics , philosophy , geometry

Pluripotency and self-renewal of embryonic stem cells (ESCs) are marked by core transcription regulators such as Oct4, Sox2, and Nanog. Another important marker of pluripotency is the long noncoding RNA (lncRNA). Here, we ind that a novel long noncoding RNA (lncRNA) Lx8-SINE B2 is a marker of pluripotency. LncRNA Lx8-SINE B2 is enriched in ESCs and downregulated during ESC differentiation. By rapid amplification of cDNA ends, we identified the full-length sequence of lncRNA Lx8-SINE B2 . We further showed that transposable elements at upstream of lncRNA Lx8-SINE B2 could drive the expression of lncRNA Lx8-SINE B2 . Furthermore, ESC-specific expression of lncRNA Lx8-SINE B2 was driven by Oct4 and Sox2. In summary, we identified a novel marker lncRNA of ESCs, which is driven by core pluripotency regulators.

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