The Outer Retinal Membrane Protein 1 Could Inhibit Lung Cancer Progression as a Tumor Suppressor | Zendy

Min Zhang | Zendy; Jun Jiang | Zendy; Cui Ma | Zendy

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The Outer Retinal Membrane Protein 1 Could Inhibit Lung Cancer Progression as a Tumor Suppressor

Author(s) -

Min Zhang,

Jun Jiang,

Cui Ma

Publication year - 2021

Publication title -

computational and mathematical methods in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.462

H-Index - 48

eISSN - 1748-6718

pISSN - 1748-670X

DOI - 10.1155/2021/6651764

Subject(s) - lung cancer , carcinogenesis , biomarker , cancer research , biology , retinal , cancer , suppressor , tumor progression , lung , pathology , oncology , medicine , biochemistry

Some related reports indicate that the outer retinal membrane protein 1 (ROM1) functions importantly in the regulation of the biological process of tumor. Nevertheless, studies towards the role of ROM1 in lung cancer are few. Here, our data demonstrated that ROM1 displayed a relation with lung cancer tumorigenesis and development. In the Tumor Genome Atlas (TCGA) cohort, reduced ROM1 level was observed in lung cancer tissues, instead of normal tissues. After bioinformatics analysis, the data revealed that ROM1 level was associated with the tumor stage. Additional results indicated that highly expressed ROM1 exhibited a positive correlation with the overall survival rate, and ROM1 was probably a promising prognostic biomarker of lung cancer. Additionally, our results indicated that knocking out ROM1 could promote cell proliferation, migration, and invasion. Our data conclusively demonstrated that ROM1 modulated lung cancer tumorigenesis and development, as a prognosis and treatment biomarker.

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