Mitochondrial Complex I Deficiency among Egyptian Pediatric Patients with Steroid-Resistant Nephrotic Syndrome | Zendy

Doaa M. Abdou | Zendy; AbdelAal Mohamed | Zendy; Mohamed Abdulhay | Zendy; Sara El Khateeb | Zendy

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Mitochondrial Complex I Deficiency among Egyptian Pediatric Patients with Steroid-Resistant Nephrotic Syndrome

Author(s) -

Doaa M. Abdou,

AbdelAal Mohamed,

Mohamed Abdulhay,

Sara El Khateeb

Publication year - 2021

Publication title -

international journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.551

H-Index - 29

eISSN - 2090-2158

pISSN - 2090-214X

DOI - 10.1155/2021/6645373

Subject(s) - nephrotic syndrome , medicine , focal segmental glomerulosclerosis , nephrocalcinosis , proteinuria , glomerulosclerosis , gastroenterology , renal biopsy , minimal change disease , pathological , biopsy , kidney

Results Positive consanguinity was a remarkable finding in 44 patients among the SRNS group (73%), compared with 33 patients among the SSNS group (55%). Complex I activity was significantly lower in the SRNS group (0.2657 ± 0.1831 nmol/ml/min), than in the SSNS group (0.4773 ± 0.1290 nmol/ml/min) ( p < 0.001). There was a significant positive correlation between complex I activity and the heaviness of proteinuria among the SRNS group ( r 0.344, p < 0.001). There were statistically significant differences in serum C3 and C4 levels between both groups ( p < 0.001, 0.053, respectively).Conclusion Mitochondrial complex I deficiency in patients who have a nephrotic syndrome complaint may play a role in their responsiveness to steroid therapy and the development of SRNS and even the prognosis of their illness.

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