Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms | Zendy

Jiaxin Ren | Zendy; Chao Li | Zendy; Xiuli Yan | Zendy; Yang Qu | Zendy; Yi Yang | Zendy; ZhenNi Guo | Zendy

Open Access

Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms

Author(s) -

Jiaxin Ren,

Chao Li,

Xiuli Yan,

Yang Qu,

Yi Yang,

ZhenNi Guo

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/6643382

Subject(s) - crosstalk , oxidative stress , ischemic stroke , microbiology and biotechnology , neuroscience , medicine , biology , bioinformatics , chemistry , ischemia , cardiology , engineering , electronic engineering

Oxidative stress is a key cause of ischemic stroke and an initiator of neuronal dysfunction and death, mainly through the overproduction of peroxides and the depletion of antioxidants. Ferroptosis/oxytosis is a unique, oxidative stress-induced cell death pathway characterized by lipid peroxidation and glutathione depletion. Both oxidative stress and ferroptosis/oxytosis have common molecular pathways. This review summarizes the possible targets and the mechanisms underlying the crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke. This knowledge might help to further understand the pathophysiology of ischemic stroke and open new perspectives for the treatment of ischemic stroke.

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