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Staphylococcus aureus  is a major human pathogen present on a third of the healthy population. The bacterium possesses an extensive arsenal of virulence factors. The pathogenicity is linked with  S. aureus  high plasticity and its exceptional ability to incorporate foreign genetic material. The aim of the present study was to perform molecular characterization of  Staphylococcus aureus  strains isolated from the clinical environment of the CHU-Z Abomey-Calavi/Sô-Ava. Isolation of  Staphylococcus aureus  bacterium was performed on Chapman agar. Toxin production by isolated  S. aureus  strains was investigated using the radial immunoprecipitation technique. A colorimetric assay was used to evaluate  Staphylococcus aureus  lipase (SA-Lipase) production. Finally, the expression of antibiotic resistance genes and genes encoding toxins production was investigated. Our data suggest that none of the isolated  Staphylococcus aureus  strains expressed the investigated toxin genes. Interestingly, SA-Lipase was produced by 14.28% of our isolated  S. aureus  strains. The  mec A gene was present in 57.14% of the isolated strains, while PVL and TSST-1 genes were identified in 2.85 and 7.14% of  S. aureus,  respectively. Significant genetic diversity was observed along the hospital environment  S. aureus  strains. The present study reveals the level of virulence of  S. aureus  strains isolated in the different units of CHU-Z Abomey Calavi/Sô-Ava through the production of lipase, PVL, and epidermolysins. The molecular study has favored a genetic characterization within the isolated strains.

biomed research international

Pathogenicity and Molecular Characterization of Staphylococcus aureus Strains Isolated from the Hospital Environment of CHU-Z Abomey-Calavi/Sô-Ava (Benin)