Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation | Zendy

Duy Ngoc Nguyen | Zendy; Phu Van Dang | Zendy; Quoc Anh Le | Zendy; Lan Thi Kim Nguyen | Zendy; Nguyễn Quốc Hiến | Zendy; Ngan Tran | Zendy; Ha Le Bao Tran | Zendy; Tuấn Đình Phan | Zendy; Ha Manh Bui | Zendy

Open Access

Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation

Author(s) -

Duy Ngoc Nguyen,

Phu Van Dang,

Quoc Anh Le,

Lan Thi Kim Nguyen,

Nguyễn Quốc Hiến,

Ngan Tran,

Ha Le Bao Tran,

Tuấn Đình Phan,

Ha Manh Bui

Publication year - 2021

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2021/6635022

Subject(s) - chemistry , selenium , nanoparticle , transmission electron microscopy , irradiation , nanotoxicology , nanomaterials , nuclear chemistry , radiochemistry , nanotechnology , toxicity , materials science , organic chemistry , physics , nuclear physics

Owing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ-irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS were characterised by UV-Vis spectroscopy, transmission electron microscopy, and energy-dispersive X-ray (EDX) analysis. Results revealed that the as-obtained SeNP/OCS powder exhibits high purity. The SeNP/OCS solution’s stability test results indicated that the SeNP/OCS solution stored at 4°C exhibits good stability for 60 days. The SeNP/OCS solution was unstable at ambient temperature, and SeNP/OCS exhibited agglomeration after about 15 days. SeNP/OCS products recovered the total white blood cells of γ-ray irradiated mice. The SeNP/OCS product, which was synthesised by a green approach, with high purity and efficient recuperation of white blood cells, can be used potentially as a functional supplement to assist cancer radiotherapy patients.

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