Methodological Considerations in N-of-1 Trials of Traditional Chinese Medicine | Zendy

Haiyin Huang | Zendy; Jiaqi An | Zendy; Lizhi Lu | Zendy; Wang Ming-li | Zendy; Huijia Chen | Zendy; Xinlin Chen | Zendy; Lihua Shen | Zendy

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Methodological Considerations in N-of-1 Trials of Traditional Chinese Medicine

Author(s) -

Haiyin Huang,

Jiaqi An,

Lizhi Lu,

Wang Ming-li,

Huijia Chen,

Xinlin Chen,

Lihua Shen

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/6634134

Subject(s) - traditional chinese medicine , quality (philosophy) , clinical trial , alternative medicine , research design , medicine , psychology , affect (linguistics) , management science , clinical study design , statistical analysis , traditional medicine , epistemology , mathematics , statistics , engineering , pathology , philosophy , communication

More and more scholars choose N-of-1 trials for TCM clinical research. However, the quality of the experimental designs was uneven. Accumulating more than eight years of experience in exploring the N-of-1 trials of TCM, the authors and their team searched the related literature in main Chinese and English databases, referenced to relevant Chinese and international guidelines. The design, implementation, and data analysis of N-of-1 trials of TCM are still in in-depth exploration and practice. “Carryover effect” may affect the design and quality of the trials. Individualized treatment should be guided by the classic theories of TCM. It is expected to formulate reasonable observation periods and pairs and closely integrate individual and group statistical analysis.

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