Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases | Zendy

Xingyun Xu | Zendy; Zhigang Miao | Zendy; Miao Sun | Zendy; Bo Wan | Zendy

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Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases

Author(s) -

Xingyun Xu,

Zhigang Miao,

Miao Sun,

Bo Wan

Publication year - 2021

Publication title -

international journal of genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.705

H-Index - 24

eISSN - 2314-4378

pISSN - 2314-436X

DOI - 10.1155/2021/6632719

Subject(s) - epigenome , offspring , epigenetics , biology , dna methylation , sperm , genetics , embryo , histone , phenotype , pregnancy , gene expression , gene

The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.

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