Effect of Yiqi Huoxue Granules on Platelet Activation Induced by Thrombin | Zendy

Zhen Lei | Zendy; Shuibo Gao | Zendy; Wang Xinzhou | Zendy; Haixia Gao | Zendy; Yongjun Han | Zendy; Zhentao Wang | Zendy; Hong Wu | Zendy

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Effect of Yiqi Huoxue Granules on Platelet Activation Induced by Thrombin

Author(s) -

Zhen Lei,

Shuibo Gao,

Wang Xinzhou,

Haixia Gao,

Yongjun Han,

Zhentao Wang,

Hong Wu

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/6622848

Subject(s) - platelet , thrombin , platelet activation , chemistry , phosphorylation , p38 mitogen activated protein kinases , endocrinology , medicine , pharmacology , biochemistry , mapk/erk pathway

Objective To study the effects of Yiqi Huoxue (YQHX) granules on platelet activation and aggregation induced by thrombin.Methods The effect of YQHX on platelet aggregation rate was detected by platelet aggregation instrument; the effect of YQHX on thrombosis time was observed by the mouse mesentery thrombosis model. DAMI cells were induced to transform into platelet-like granules using PMA, and the effects of SCH (PAR-1 inhibitor) on thrombin-induced changes in platelet intracellular calcium concentration, PAR-1 protein expression, and phosphorylation of MAPK were examined.Results Compared with the control group, the platelet aggregation rate, PAR-1 protein expression, phosphorylation of ERK1/2, and p38 protein in the YQHX group decreased ( P < 0.05), and there was no significant difference between the YQHX + SCH group and YQHX group ( P > 0.05).Conclusion YQHX suppresses the platelet activation induced by thrombin by inhibiting PAR-1 expression.

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