MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders | Zendy

Yang Yu | Zendy; Dan-yang Liu | Zendy; Xue-shen Chen | Zendy; Ling Zhu | Zendy; Lihong Wan | Zendy

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MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders

Author(s) -

Yang Yu,

Dan-yang Liu,

Xue-shen Chen,

Ling Zhu,

Lihong Wan

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/6467679

Subject(s) - endoplasmic reticulum , unfolded protein response , fight or flight response , neuroscience , stress (linguistics) , microbiology and biotechnology , biology , medicine , biochemistry , gene , linguistics , philosophy

The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in many ER stress-related diseases with a protective effect. Here, we review the function of MANF based on its structure in neurological and metabolic disorders and summarize its potential applications in disease diagnosis and therapies.

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