Open AccessSynthesis of a New Type of Trans-Decalin Vitamin D Analogue through a Dyotropic Ring Expansion
Author(s) -
Hugo Santalla,
Uxía Gómez-Bouzó,
Irene Sánchez-Sanz,
Yagamare Fall
Publication year - 2021
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.436
H-Index - 50
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2021/6429427
Subject(s) - chemistry , decalin , ring (chemistry) , stereochemistry , transformation (genetics) , triol , organic chemistry , diol , biochemistry , catalysis , gene
A new vitamin D analogue with a trans-fused decalin as the CD-ring system and containing a sulphur atom in the side chain has been synthesized in our research group. The obtention of this analogue is based on a recently discovered transformation of hydrindane cores into decalins through a dyotropic ring expansion in very mild conditions.
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