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lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified  GAU1  as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking percentile = 99.75%,  P  < 10 −50 ), which is coexpressed with the potential oncogene  GALNT8  (Spearman rho = 0.67,  P  = 2.44 × 10 −23 , TCGA dataset  n  = 184). Experimental data revealed that  GAU1  regulates the expression of  GALNT8 . The overexpression of either  GAU1  or  GALNT8  significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC ( P  = 3.04 × 10 −2 ), while silencing of  GAU1  or  GALNT8  suppressed the cancer cell proliferation and induced the CRC cell line resistance to oxaliplatin  in vitro  treatment. Our results suggested that the previously less studied  GAU1  and  GALNT8  may play as CRC prognosis markers and potential targets for chemotherapy treatment.

lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression