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Background   Artemisia negrei  L. ( A. negrei ) is a medicinal and aromatic plant belonging to the family Asteraceae that is more widespread in the folded Middle Atlas Mountains, Morocco.Materials and Methods   This study was run to investigate the phytochemical composition and antioxidant, antibacterial, and antifungal activities of  Artemisia negrei  L. essential oil. This oil was extracted from the fresh plant material by using the Clevenger apparatus. The phytochemical composition was characterized by GC-MS. The antioxidant activity was evaluated using different methods including DPPH,  β -carotene bleaching, and total antioxidant capacity. The antibacterial activity was tested vs. multidrug-resistant bacteria including both Gram-negative and Gram-positive using inhibition zones in agar media and minimum inhibitory concentration (MIC) bioassays. The antifungal activity was conducted on  Candida albicans ,  Aspergillus niger ,  Aspergillus flavus,  and  Fusarium oxysporum  using a solid medium assay.Results   The chromatographic characterization of essential oils of  A. negrei  revealed the presence of 34 compounds constituting 99.91% of the total essential oil. The latter was found to have promising antioxidant activity by all bioassays used such as DPPH,  β- carotene bleaching, and total antioxidant capacity. The results obtained showed that our plant oils had potent antibacterial activity towards Gram-negative ( E. coli  57,  E. coli  97,  K. pneumonia , and  P. aeruginosa)  and Gram-positive ( S. aureus ), so that the maximum inhibition zones and MIC values were around 18–37 mm and 3.25 to 12.5 mg/mL, respectively. The oil also showed antifungal activity towards  Candida albicans ,  Fusarium oxysporum,  and  Aspergillus Niger  except for flavus species.Conclusion   The findings obtained in the work showed that  A. negrei  can serve as a valuable source of natural compounds that can be used as a new weapon to fight radical damage and resistant microbes.

Chemical Analysis and Antioxidant and Antimicrobial Activity of Essential oils from Artemisia negrei L. against Drug-Resistant Microbes