Poly Lactic-Co-Glycolic Acid- (PLGA-) Loaded Nanoformulation of Cisplatin as a Therapeutic Approach for Breast Cancers | Zendy

Saad Alkahtani | Zendy; Saud Alarifi | Zendy; Gadah Albasher | Zendy; Mohammed AlZharani | Zendy; Nada H. Aljarba | Zendy; Mohammed H.A. Almarzoug | Zendy; Norah M. Alhoshani | Zendy; Norah S. AL–Johani | Zendy; Hani Alothaid | Zendy; Abdullah A. Alkahtane | Zendy

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Poly Lactic-Co-Glycolic Acid- (PLGA-) Loaded Nanoformulation of Cisplatin as a Therapeutic Approach for Breast Cancers

Author(s) -

Saad Alkahtani,

Saud Alarifi,

Gadah Albasher,

Mohammed AlZharani,

Nada H. Aljarba,

Mohammed H.A. Almarzoug,

Norah M. Alhoshani,

Norah S. AL–Johani,

Hani Alothaid,

Abdullah A. Alkahtane

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/5834418

Subject(s) - cisplatin , plga , glycolic acid , cytotoxicity , pharmacology , drug , bioavailability , toxicity , drug delivery , chemistry , apoptosis , cancer research , chemotherapy , medicine , lactic acid , in vitro , biochemistry , biology , organic chemistry , bacteria , genetics

Despite recent advancements in cisplatin ( cis -diamminedichloroplatinum II) and other platinum-based chemotherapeutic drugs for treating solid tumors, their uses are limited by either in terms of toxicity and/or acquired drug resistance. These side effects have a dangerous problem with higher dose for severe patients. To overcome the low therapeutic ratio of the free drug, a polymeric nanoparticle drug delivery system has been explored promoting delivery of cisplatin to tumors. Recently, the applications of nanoparticles (NPs) have been underlined for encouraging the effects of chemotherapeutic drugs in cancerous cells. The intention of this project is to assess the potential of poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for enhancing the effects of anticancer drug cisplatin. For the purpose, we have synthesized PLGA-cisplatin nanoparticles for increasing its bioavailability and studied the comparative cytotoxicity of free cisplatin and PLGA-cisplatin against MCF-7 cancer cell lines and HEK-293 normal cell lines. We have also analyzed the hallmarks of PLGA-cisplatin-induced apoptosis. The outcomes of this study may provide the possibility of delivery of anticancer drug to their specific site, which could minimize toxicity and optimize the drug efficacy.

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