Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma | Zendy

Reyna Daya | Zendy; C. Wingfield | Zendy; P. Sotshoda | Zendy; Faheem Seedat | Zendy; Saajidah Bulbulia | Zendy; M. D. Simmons | Zendy; Melanie Louw | Zendy; Zaheer Bayat | Zendy

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Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma

Author(s) -

Reyna Daya,

C. Wingfield,

P. Sotshoda,

Faheem Seedat,

Saajidah Bulbulia,

M. D. Simmons,

Melanie Louw,

Zaheer Bayat

Publication year - 2021

Publication title -

case reports in endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.26

H-Index - 6

eISSN - 2090-6501

pISSN - 2090-651X

DOI - 10.1155/2021/5593920

Subject(s) - medicine , cushing syndrome , paraganglioma , neuroendocrine tumors , thyroid , small cell lung carcinoma , pathology , medullary cavity , lung , endocrinology , small cell carcinoma

Paraneoplastic or ectopic Cushing's syndrome (CS) is a rare cause of endogenous hypercortisolism. It is due to ectopic adrenocorticotropic hormone (ACTH) secretion and has been reported in association with a variety of neuroendocrine tumors such as small-cell lung carcinoma, carcinoid tumors, and medullary carcinoma of the thyroid. Paragangliomas (PGLs) are rare neuroendocrine tumors that can secrete catecholamines. Case reports and reports of ectopic ACTH secretion from metastatic PGLs causing CS are exceedingly rare. We present a case of a 38-year-old female, who presented with typical signs, symptoms, and complications of CS, secondary to a PGL with widespread metastases, which eventually led to her demise.

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