On-Demand Release of Drug from Magnetic Nanoparticle-Loaded Alginate Beads | Zendy

Dung The Nguyen | Zendy; Nguyet-Minh Nguyen | Zendy; Duc-Minh Vu | Zendy; Trần Minh Đức | Zendy; Van-Thao Ta | Zendy

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On-Demand Release of Drug from Magnetic Nanoparticle-Loaded Alginate Beads

Author(s) -

Dung The Nguyen,

Nguyet-Minh Nguyen,

Duc-Minh Vu,

Trần Minh Đức,

Van-Thao Ta

Publication year - 2021

Publication title -

journal of analytical methods in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.407

H-Index - 25

eISSN - 2090-8865

pISSN - 2090-8873

DOI - 10.1155/2021/5576283

Subject(s) - coprecipitation , drug , drug delivery , nanoparticle , magnetic nanoparticles , controlled release , magnetite , targeted drug delivery , magnetite nanoparticles , chemistry , materials science , nanotechnology , pharmacology , medicine , organic chemistry , metallurgy

Targeted delivery and controlled release of drugs has been considered to be an important therapeutic approach since it could allow a better treatment efficiency and less side effects. In this research, magnetite Fe 3 O 4 nanoparticles were successfully synthesized via the coprecipitation method and then loaded in alginate beads with berberine as a drug model for drug release application. Various factors such as pH values of the suspended environment and surface modifications of the drug carrier could be exploited to adjust the amount of drug release. More importantly, the amount of drug release could be effectively controlled by an on-off switching operation of a static magnetic field.

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