KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer | Zendy

Jing Chen | Zendy; Cuicui Zhao | Zendy; Fei-Ran Chen | Zendy; Guowei Feng | Zendy; Fei Luo | Zendy; Tao Jiang | Zendy

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KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer

Author(s) -

Jing Chen,

Cuicui Zhao,

Fei-Ran Chen,

Guowei Feng,

Fei Luo,

Tao Jiang

Publication year - 2021

Publication title -

journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 54

eISSN - 1687-8469

pISSN - 1687-8450

DOI - 10.1155/2021/5572402

Subject(s) - pancreatic cancer , gene knockdown , medicine , proliferating cell nuclear antigen , immunohistochemistry , cancer research , cell growth , in vivo , cancer , cell , cell culture , oncology , pathology , biology , microbiology and biotechnology , genetics

KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of Ki-67 and PCNA. Xenograft assay showed a similar result in vivo. KIF20B is a potential therapeutic target in pancreatic cancer.

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