Advances in the Development of Biomarkers for Poststroke Epilepsy | Zendy

Mengke Liang | Zendy; Liren Zhang | Zendy; Zhi Geng | Zendy

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Advances in the Development of Biomarkers for Poststroke Epilepsy

Author(s) -

Mengke Liang,

Liren Zhang,

Zhi Geng

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/5567046

Subject(s) - epilepsy , stroke (engine) , medicine , biomarker , intensive care medicine , excitatory amino acid transporter , glutamate receptor , bioinformatics , psychiatry , receptor , biology , mechanical engineering , biochemistry , engineering

Stroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as interleukin-6 (IL-6), tumor necrosis factor- α (TNF- α ), glutamate, and S100 calcium-binding protein B (S100B) in blood are associated with the occurrence of PSE. This review is aimed at summarizing the progress on potential biomarkers of PSE.

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