Fibronectin 1: A Potential Biomarker for Ovarian Cancer | Zendy

Huijing Bao | Zendy; Qianyu Huo | Zendy; Yuan Qin | Zendy; Chen Xu | Zendy

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Fibronectin 1: A Potential Biomarker for Ovarian Cancer

Author(s) -

Huijing Bao,

Qianyu Huo,

Yuan Qin,

Chen Xu

Publication year - 2021

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2021/5561651

Subject(s) - ovarian cancer , biomarker , cancer research , biology , kegg , fibronectin , gene , gene expression , cancer , oncology , cell , medicine , genetics , gene ontology

Methods OVCAR3 and A2780 are the two common cell lines that are used for ovarian cancer studies. The different invasion and migration abilities were observed by scratch tests and transwell experiments in our preliminary study. Gene chip was used to screen the expression gene in these two different cell lines, and then, the differentially expressed genes (at least 2-fold difference, P value < 0.05) were analyzed using KEGG.Result Fibronectin 1 (FN1) was found to be the most strongly correlated with the invasion and migration abilities of the OVCAR3 cells. Real-time PCR and FN1 knockout cell line was conducted and confirmed this finding. Based on the Oncomine database analysis, comparing with normal people, ovarian cancer patients exhibited high levels of FN1 expression. Additionally, higher FN1 expression was found in patients with higher FIGO stages of cancer.Conclusion FN1 could be a new biomarker for ovarian cancer detection and progress indicator.

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