Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis | Zendy

Amir Hossein Aalami | Zendy; Hossein Abdeahad | Zendy; Mohammad Mesgari | Zendy; Thozhukat Sathyapalan | Zendy; Amirhossein Sahebkar | Zendy

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Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Author(s) -

Amir Hossein Aalami,

Hossein Abdeahad,

Mohammad Mesgari,

Thozhukat Sathyapalan,

Amirhossein Sahebkar

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/5557309

Subject(s) - diagnostic odds ratio , meta analysis , medicine , bladder cancer , likelihood ratios in diagnostic testing , biomarker , receiver operating characteristic , angiogenin , odds ratio , area under the curve , cochrane library , oncology , urinary system , urine , urology , cancer , gastroenterology , biology , biochemistry , angiogenesis

Aims Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients' urine with bladder neoplasm.Methods We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10 th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR + ), negative likelihood ratio (LR − ), Q ∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients.Results Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66–0.75), specificity of 0.78 (95% CI: 0.73–0.81), LR + of 3.34 (95% CI: 2.02–5.53), LR − of 0.37 (95% CI: 0.32–0.44), DOR of 9.99 (95% CI: 4.69–21.28), and AUC of 0.789 and Q ∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa.Conclusion This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.

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