An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line | Zendy

Alexandra Ghițu | Zendy; Ioana Zinuca Pavel | Zendy; Ştefana Avram | Zendy; Brigitta Kis | Zendy; Daliana Minda | Zendy; Cristina Dehelean | Zendy; Valentina Buda | Zendy; Roxana Folescu | Zendy; Corina Danciu | Zendy

Open Access

An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line

Author(s) -

Alexandra Ghițu,

Ioana Zinuca Pavel,

Ştefana Avram,

Brigitta Kis,

Daliana Minda,

Cristina Dehelean,

Valentina Buda,

Roxana Folescu,

Corina Danciu

Publication year - 2021

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2021/5552664

Subject(s) - apigenin , in vivo , melanoma , chorioallantoic membrane , angiogenesis , cell culture , cell growth , in vitro , cancer research , cytotoxic t cell , chemistry , pharmacology , biology , biochemistry , flavonoid , microbiology and biotechnology , genetics , antioxidant

One of the most important class of natural compounds with successful preclinical results in the management of cancer is the flavonoids. Due to the plethora of biological activities, apigenin (4′,5,7 trihydroxyflavone) is a main representant of the flavone subclass. Although the antiproliferative and antiangiogenic effects of apigenin were studied on a significant number of human and murine melanoma cell lines, in order to complete the data existing in the literature, the aim of this study is to evaluate the in vitro effect of apigenin on SK-MEL-24 human melanoma cell line as well as in vivo on tumor angiogenesis using the aforementioned cell line on the chorioallantoic membrane assay. Results have shown that in the range of tested doses, the phytocompound presents significant antiproliferative, cytotoxic, and antimigratory potential at 30 μ M, respectively, 60 μ M. Moreover, the phytocompound in both tested concentrations limited melanoma cell growth and migration and induced a reduced angiogenic reaction limiting melanoma cell development.

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