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The aim of this study is to perform phytochemical screening of the leaves of  Piliostigma reticulatum  and  Piliostigma thonningii , to determine the phenolic, flavonoids, tannins, and sugars content in their methanolic extracts, evaluate their antioxidant activity using the DPPH and the ABTS tests, and test their anti-inflammatory effect in vitro using the heat-induced albumin denaturation inhibition method. Phytochemical screening revealed the presence of polyphenols and alkaloids in the leaves of both plants. Yields of the extracts in this study ranged from 7% to 18% for  P. reticulatum  and 4% to 16% for  P. thonningii . The phenolic content in the methanolic extract of  P. reticulatum  is 74.66 ± 1.76  μ g GAE/mL, which is significantly higher than that of  P. thonningii  (56.54 ± 1.24  μ g GAE/mL). Both plants showed good antioxidant activity. In fact, for the DPPH test, the IC50 value is 8.88 ± 0.11  μ g/mL for  P. reticulatum  and 17.64 ± 0.68  μ g/mL for  P. thonningii . For the ABTS assay, the IC 50  values of the two plants are, respectively, 9.78 ± 1.83  μ g/mL and 13.47 ± 2.62  μ g/ml, statistically comparable and significantly higher than the IC 50  of the standard 30.76 ± 0.18  μ g/ml. Leaf extracts from both plants were effective against heat-induced denaturation of albumin. The activity of  P. reticulatum  is indeed comparable to that of the standard with an IC 50  value of 121.43 ± 1.55  μ g/mL and higher than that of  P. thonningii  with an IC 50  value of 170.15 ± 1.09  μ g/mL. These results show that both plants exhibit significant antioxidant and anti-inflammatory activities. Therefore, their chemical compounds could have potential applications as antioxidant and anti-inflammatory drugs.

advances in pharmacological and pharmaceutical sciences

Study of the Phytochemical Composition, the Antioxidant and the Anti-Inflammatory Effects of Two Sub-Saharan Plants: Piliostigma reticulatum and Piliostigma thonningii