Hypoglycemic Effect of Vitexin in C57BL/6J Mice and HepG2 Models | Zendy

Weidong Xu | Zendy; Jiayao Li | Zendy; Weipeng Qi | Zendy; Ye Peng | Zendy

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Hypoglycemic Effect of Vitexin in C57BL/6J Mice and HepG2 Models

Author(s) -

Weidong Xu,

Jiayao Li,

Weipeng Qi,

Ye Peng

Publication year - 2021

Publication title -

journal of food quality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.568

H-Index - 43

eISSN - 1745-4557

pISSN - 0146-9428

DOI - 10.1155/2021/5535476

Subject(s) - vitexin , insulin resistance , chemistry , apigenin , pharmacology , insulin , metformin , endocrinology , biochemistry , flavonoid , medicine , biology , antioxidant

Apigenin-8-C-glucoside (vitexin), a natural phytochemical contained in hawthorn, has been reported to have versatile beneficial bioactivities, such as antioxidation, anticancer property, and adipogenesis inhibition. The present research aimed to determine the influence of vitexin on insulin resistance elicited by HFD in mice and HepG2 cells. Vitexin markedly alleviated body weight gain and improved glucose and insulin intolerance induced by HFD. Vitexin partially normalized blood glucose, cholesterol, TNF-α, and hepatic lipid content. Moreover, vitexin recovered the reduced glucose uptake induced by glucosamine. The present results indicate that vitexin prevents HFD-induced insulin resistance.

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